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CBE Graduate Student Research Symposium
October 18, 2013 @ 1:00 pm - 6:30 pm
Student Lectures, 1:00 pm in the Screening Room
Keynote Presentation by Dr. Michael D. Reilly: Pharmaceutical Applications of Metabolomics, 2:00pm in the Screening Room
Student Reception and Poster Competition, 3:30 pm in the Atrium
CBE Student-Alumni Mixer 5:30PM (RSVP cbe-chair@buffalo.edu)
Keynote Abstract
The metabolome, or the total compliment of small molecules in a living system that includes endogenous and introduced species, reflects the overall global biochemical state of an organism. Changes in the functional genome, transcriptome and proteome are closely tied to changes in the metabolome. Metabolomics (or metabonomics) is the comprehensive measurement of the metabolome and how it changes in response to external stressors. In Pharmaceutical R&D, this information can be used to deduce the relationship between a perturbation (such as disease or pharmacological intervention to disease) and the affected biochemical pathways, yielding mechanistic information and biomarkers that report upon the perturbation. These biomarkers can in turn inform and accelerate the discovery of safe and efficacious drugs. This talk will provide a background on the technology and present several examples of how it has been employed in mainstream pharmaceutical R&D.