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The ALEVRIADOU VASCULAR MECHANOBIOLOGY LABORATORY (AVML) is committed to responsibly conducting research on vascular cell responses to changes in the cell’s mechanochemical environment and on the contribution of these responses to cardiovascular disease initiation and progression.

The AVML goal is to elucidate the molecular mechanisms that lead to vascular endothelial cell dysfunction, a key factor (and potential target for prevention and treatment) of cardiovascular diseases/conditions, such as atherosclerosis/coronary artery disease, cardiac ischemia/reperfusion injury, hypertension, heart failure, diabetes, etc.

The AVML areas of expertise include:

1. in vitro cellular systems that reproduce the mechanochemical environment in vascular health and disease (shear stress and tensile stress),
2. study of endothelial cell oxidative and glycolytic metabolic and lipid metabolic pathways, intracellular signaling (emphasis on mitochondria, calcium, reactive oxygen species, and nitric oxide), gene expression, protein synthesis, and cell survival, and
3. study of endothelial cell-derived extracellular vesicles as drivers of cardiovascular diseases and potential therapeutic targets, including (mitochondrial and other) cargo characterization and paracrine effects.

The AVML is directed by B. Rita Alevriadou, PhD, SUNY Empire Innovation Professor, Department of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences, School of Engineering and Applied Sciences, University at Buffalo – The State University of New York.

The AVML gratefully acknowledges the funding sources that currently support and/or have supported our research efforts.