Selected publications
Cineus, Roy; Abozeid, S. M.; Sokolow, G. E.; Spernyak, J. A.; Morrow, J. R.* “Fe(III) T1 MRI probes containing phenolate or hydroxypyridine-appended triamine chelates and a coordination site for bound water” Inorg Chem 2023, 62, 16513-16522. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.3c02344
Chowdhury, M. S. I.; Kras, E. K.; Turowski, S. G.; Spernyak, J. A.; Morrow, J. R.*“Liposomal MRI probes containing encapsulated or amphiphilic Fe(III) Coordination complexes” Biomaterials Sci 2023, 11, 5942-5954. https://pubs.rsc.org/en/content/articlelanding/2023/bm/d3bm00029j
Raymond, J. J.: Abozeid, S. M.; Sokolow, G. E.; Bond, C. J.; Yap, C. E.; Nazarenko, A. Y.; Morrow, J. R.* “Co(II) complexes of tetraazamacrocycles appended with amide or hydroypropyl groups as paraCEST agents” Dalton Trans, 2023, 52, 9831-9839. https://pubs.rsc.org/en/content/articlelanding/2023/dt/d3dt01572f
Pinti, J. C.;Kras, E. A.; Patel, A.;Schrier, C. L.; Stoj,C. S.; Morrow, J. R. “Magnetization of Yeast by Labeling with Iron Complexes: An Undergraduate Laboratory Experiment” J. Chem. Ed. 2022, 99, 3752-3756. https://pubs.acs.org/doi/10.1021/acs.jchemed.2c00791
Morrow, J. R.;* Raymond, J. R.; Chowdhury, M. S. I.; Sahoo, P. R. “Redox-responsive MRI Probes Based on First-row Transition Metal Complexes” Inorg. Chem. 2022, 61, 14487-14499. https://pubs.acs.org/doi/10.1021/acs.inorgchem.2c02197
Kras, E.; Snyder, E.; Sokolow, G. E.; Morrow, J. R.* “Distinct coordination chemistry of Fe(III)-based MRI probes” Acc. Chem. Res. 2022, 55, 1435-1444. https://pubs.acs.org/doi/full/10.1021/acs.accounts.2c00102
Sokolow, G. E.; Crawley, M. R.; Morphet, D. R.; Asik, D.; Spernyak, J. A.; McGray, J. R.; Cook, T. R.;* and Morrow, J. R.* “A metal organic polyhedron with four Fe(III) centers producing enhanced T1 magnetic resonance imaging contrast in tumors” Inorg. Chem. 2022, 61, 2603-2011. https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c03660
Abozeid, S. M.; Chowdhury, Md. S. I.; Asik, D.; Spernyak, J.A.; Morrow, J. R.* “Liposomal Fe(III) Macrocyclic complexes with hydroxypropyl pendants as MRI probes” ACS Appl Bio Mater2021, 4, 7951-7960. https://pubs.acs.org/doi/10.1021/acsabm.1c00879
Kras, E. A.; Abozeid, S. M.; Eduardo, W.; Spernyak, J. A.; Morrow, J. R.* “Comparison of phosphonate, hydroxypropyl and carboxylate pendants in Fe(III) macrocyclic complexes as MRI contrast agents” J. Inorg. Biochem. 2021, 225, 111594. https://www.sciencedirect.com/science/article/abs/pii/S0162013421002415
Asik, D. A.; Abozeid, S. M.; Turoski, S. G.; Spernyak, J. A.; Morrow, J. R.* “Dinuclear Fe(III) hydroxypropyl-appended macrocyclic complexes as MRI probes” Inorg. Chem. 2021, 60, 8651-8664. https://pubs.acs.org/doi/10.1021/acs.inorgchem.1c00634
Patel, A.; Patel, Abozeid, S. M.; Cullen, P. J.; Morrow, J. R.* “Co(II) macrocyclic complexes appended with fluorophores as paraCEST and cell CEST agents” Inorg. Chem. 2020, 59, 16531-16544. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.0c02470
Patel, A.; Asik, D.; Snyder, E. M.; Spernyak, J. A.; Cullen, P. J.; Morrow, J. R.* “Saccharomyces cerevisiae and Candida albicans Yeast Cells Labeled with Fe(III) Complexes as MRI Probes” Magnetochemistry 2020, 6, 41 DOI:10.3390/magnetochemistry6030041. https://www.mdpi.com/2312-7481/6/3/41
Asik, D.; Smolinski, R.; Abozeid, S. M.; Michell, T. B.; Spernyak, J. A.; Morrow, J. R.* “Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups” Molecules 2020, 25, 2291; doi:10.3390/molecules25102291. https://www.mdpi.com/1420-3049/25/10/2291
Abozeid, S. M.; Asik, D.; Sokolow, G. E.; Nazarenko, A. Y.; Lovell, J. F.; Morrow, J. R.* “Co(II) complexes as liposomal CEST agents” Angew. Chem. Int. Ed. 2020, 59, 12093-97. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202003479
Patel, A.; Asik, D.; Snyder, E. M.; Delillo, A. E.; Cullen, P. J.; Morrow, J. R.* “Binding and release of Fe(III) complexes from glucan particles for delivery of T1 MRI contrast agents” ChemMedChem 2020, 15, 1050-1057. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202000003
Snyder, E. M.; Chowdhury, M. S. I.; Morrow, J. R.* “Co(II) and Fe(II) Triazole-Appended 4,10-diaza-15-crown-5-ether Macrocyclic Complexes for CEST MRI Applications” Inorg. Chim. Acta 2020, 509, 119649. issue in honour of Prof. Tara Dasgupta. https://www.sciencedirect.com/science/article/abs/pii/S0020169319318365
Bond, C. J.; Cineus, R.; Nazarenko, A. Y.; Spernyak, J. A.; Morrow, J. R.* “Isomeric Co(II) paraCEST agents as pH responsive MRI probes” Dalton Trans. 2020, 49, 279-284 https://pubs.rsc.org/en/content/articlehtml/2020/dt/c9dt04558a
Snyder, E. M.; Asik, D.; Abozeid, S. M.; Burgio, A.; Bateman, G.; Turowski, S. G.; Spernyak, J. A.; Morrow, J. R.* “A class of Fe(III) macrocyclic complexes with alcohol donor groups as effective T1 MRI contrast agents” Angew. Chem. Int. Ed. 2020, 59, 2414-2419. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912273
Buccella, D.; Lim, M. H.; Morrow, J. R. “Metals in Biology: from metallomics to trafficking” Inorg. Chem. 2019, 58, 13505-13508. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.9b02965
Tolman, W. B.; Balch, A. L.; Bart, S.; Cossairt, B.; Dehnen, S.; Halasyamani, P. S.; Kageyama, H.; Meyer, F.; Morrow, J. R.; Mukherjee, P. S.; Neese, F.; Power, P. P.; Sessoli, R.; Yam, V. W. W.; Zhou, H.-C. “What is Inorganic Chemistry?” Inorg. Chem. 2019, 58, 9515-9516. https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b02015
Patel, A.; Asik, D.; Spernyak, J. A.; Cullen, P.; Morrow, J. R.* “Fe(III) based bimodal imaging agents for yeast cells” J. Inorg. Biochem. 2019, 201, 11083-. Issue dedicated to Debbie Crans. https://www.sciencedirect.com/science/article/pii/S0162013419303393
Bond, C. F.; Sokolow, G. E.; Crawley, M. R.; Burns, P. J.; Cox, J. M.; Mayilmurugan, R.; Morrow, J. R.* “Exploring inner-sphere water interactions of Fe(II), Fe(II) and Co(II) complexes of 12-member macrocycles to develop CEST MRI probes” Inorg. Chem. 2019, 58, 8710-8719. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.9b01072.
Tsitovich,P. B.; Gendron F.; Nazarenko, A. Y.; Livesay, B. N.; Lopez,A. P.; Shores,M. P.; Autschbach, J. A.; Morrow, J. R.* “Low Spin Fe(III) Macrocyclic Complexes of Imidazole-appended TACN as Paramagnetic Probes” Inorg. Chem. 2018, 57, 8364-8374. https://pubs.acs.org/doi/10.1021/acs.inorgchem.8b01022
Abozeid, S. M.; Snyder E. M.; Lopez, A. P.; Steuerwald, C. M.; Sylvester,E.; Ibrahim, K. M; Zaky, R. R.; Abou-El-Nadar, H. M.; Morrow, J. R.* “Nickel(II) complexes as paramagnetic shift and paraCEST agents” Eur. J. Inorg. Chem. 2018, 1902-1908. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201800021
Abozeid, S. M.; Snyder, E. M.; Tittiris, T. Y.; Steuerwald, C. M.; Nazarenko, A. Y.; Morrow, J. R.* “Co(II) complexes with innersphere and outersphere water interactions for CEST MRI applications” Inorg. Chem. 2018, 57, 2085-2095. https://pubs.acs.org/doi/10.1021/acs.inorgchem.7b02977
Tsitovich, P. B.; Tittiris, T. Y.; Cox, J. M.; Benedict, J. B.; Morrow, J. R.* “Fe(II) and Co(II) N‑methylated CYCLEN complexes as paraSHIFT agents with large temperature dependent shifts” Dalton Trans. 2018, 47, 916-924. https://pubs.rsc.org/en/content/articlelanding/2018/dt/c7dt03812g
Tsitovich, P. B.; Kosswattaarachchi, A. M.; Crawley, M. R.; Tittiris, T. Y.; Cook, T. R.* Morrow, J. R.* “An Fe(III) Aza-macrocyclic Complex as pH-Tunable Catholyte and Anolyte for Redox-Flow Battery Applications” Chem. Eur. J. 2017, 23(61), 15327-15331. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201704381
Morrow, J. R.; Toth, E. “Next Generation MRI Contrast Agents” virtual issue, Inorg. Chem. 2017 56, 6029-34.https://pubs.acs.org/page/vi/next-gen-mri-agents
Burns, P. J.; Cox, J. M.; Morrow, J. R.* “Imidazole-appended macrocyclic complexes of Fe(II), Co(II) and Ni(II) as paraCEST agents” Inorg. Chem. 2017, 56, 4545-4554. https://pubs.acs.org/doi/10.1021/acs.inorgchem.7b00176
Tsitovich, P. B.; Cox. J. M.; Morrow, J. R.* “Gearing up for pH Shift: a Responsive Iron(II) 2-amino-6-picolyl-appendent Macrocyclic paraCEST Agent” Inorg. Chem. 2016, 55, 12001-10. https://pubs.acs.org/doi/10.1021/acs.inorgchem.6b02159
Sanders, S. A.; Morrow, J. R.* “Zn(II) Complexes that trigger a DNA conformational Switch” Special issue on metal nucleic acid interactions: state of the art in Inorg. Chim. Acta 2016, 452, 90-97. https://www.sciencedirect.com/science/article/pii/S002016931630024X
Burns, P. J.; Tsitovich, P. B.; Morrow, J. R.* “Preparation of Cobalt(II) Cages: An Undergraduate Laboratory Experiment that Produces a paraSHIFT Agent for Magnetic Resonance Spectroscopy” J. Chem. Educ. 2016, 93, 1115-1119. https://pubs.acs.org/doi/full/10.1021/acs.jchemed.5b00818
Morrow, J. R. “Virtual issue on Emerging investigators in Bioinorganic Chemistry” Inorg. Chem. 2015, 54(23), 11039-11042. https://pubs.acs.org/doi/10.1021/acs.inorgchem.5b02597
Tsitovich, P. B.; Cox,J. M.; Benedict, J. B.; Spernyak, J. A.; Morrow, J. R.* “Six-coordinate Co(II) and Fe(II) paraSHIFT agents for temperature measurement” Inorg. Chem. 2015, 55, 700-716. https://pubs.acs.org/doi/10.1021/acs.inorgchem.5b02144
Olatunde,A. O.; Bond, C. J.; Dorazio, S. J.; Daddario, M. D.; Spernyak, J. A.; Cox,J. M.; Benedict, J. B.; Morrow, J. R.* “CoII, FeII and NiII Amide-Appended Tetraazamacrocyclic Complexes as ParaCEST Agents for Thermometry” Chem. Eur. J. 2015, 21, 18290-18300. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201503125
Sanders, S. A.; Van Hall, A. K.; Morrow, J. R.* “Zn2+ Selective Switch of Duplex to Hairpin DNA” Inorg. Chem. 2015, 54, 3084-3086. https://pubs.acs.org/doi/10.1021/ic503074p
Siters, K. E.; Sander, S. A.; Devlin, J.; Morrow, J. R.* “Bifunctional Zn(II) Complexes for Recognition of Non-Canonical Thymines in DNA Bulges and G-Quadruplexes” Dalton Trans. 2014, 3708-3716. https://pubs.rsc.org/en/content/articlelanding/2015/dt/c4dt03004d
Siters, K. E.; Fountain, M. A.; Morrow, J. R.* “Selective binding of Zn(II) complexes to Human Telomeric G-quadruplex DNA” Inorg. Chem. 2014, 53, 11540-11551. https://pubs.acs.org/doi/10.1021/ic501484p
Olatunde,A. O.; Cox,J. M.; Daddario, M. D; Spernyak, J. A.; Benedict, J. B.; Morrow, J. R.* “Seven-Coordinate CoII, FeII and Six-Coordinate NiII Amide-Appended Macrocyclic Complexes as ParaCEST Agents in Biological Media” Inorg. Chem. 2014, 53, 8311-8321. https://pubs.acs.org/doi/10.1021/ic5006083
Tsitovich, P. B.; Burns, P. J.; McKay, A. M.; Morrow, J. R.* “Redox-activated MRI Contrast Agents Based on Lanthanide and Transition Metal Ions” J. Inorg. Biochem. 2014, 133, 143-154. https://www.sciencedirect.com/science/article/pii/S0162013414000208
Dorazio, S. J.; Olatunde, A. O.; Tsitovich, P. B.; Morrow, J. R.* “Comparison of Divalent Transition Metal Ion paraCEST MRI Contrast Agents” J. Biol. Inorg. Chem. 2014, 19, 191-205.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946895/[JR1]
Tsitovich, P. B.; Spernyak, J. A.; Morrow, J. R.* “A redox-activated MRI Contrast Agent that Switches between Paramagnetic and Diamagnetic States” Angew. Chem. Int. Ed. 2013, 52, 13997-14000. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201306394
Dorazio, S. J.; Olatunde, A. O.; Spernyak, J. A.; Morrow, J. R.* “CoCEST: Cobalt(II) Amide-appended ParaCEST MRI Contrast Agents” Chem. Commun. 2013, 49, 10025-10027. https://pubs.rsc.org/en/content/articlelanding/2013/CC/c3cc45000g
De Leon, A. R.; Olatunde, A. O.; Morrow, J. R.*; Achim, C.* “Binding of Eu(III) to 1,2-hydroxypyridinone-modified peptide nucleic acids” Inorg. Chem. 2012, 51, 12597-12599. https://pubs.acs.org/doi/10.1021/ic301790v
Olatunde, A.; Dorazio, S. J.; Spernyak, J. A.; Morrow, J. R.* “The NiCEST Approach: Ni(II) PARACEST MRI Contrast Agents” J. Am. Chem. Soc. 2012, 134, 18503-18505. https://pubs.acs.org/doi/10.1021/ja307909x
Dorazio, S. J.; Morrow, J. R.* “Iron(II) Complexes Containing Octadentate Tetraazamacrocycles as ParaCEST Magnetic Resonance Imaging Contrast Agents” Inorg. Chem. 2012, 51, 7448-7450. https://pubs.acs.org/doi/10.1021/ic301001u
Tsitovich, P. B.; Morrow, J. R.* “Macrocyclic ligands for Fe(II) paraCEST and Chemical Shift MRI Contrast Agents” Inorg. Chim. Acta 2012, 393, 3-11. https://www.sciencedirect.com/science/article/pii/S0020169312003702
Dorazio, S. J.; Tsitovich, P. B.; Gardina, S. A.; Morrow, J. R.* “The Reactivity of Macrocyclic Fe(II) paraCEST MRI Contrast Agents towards Biologically Relevant Anions, Cations, Oxygen or Peroxide” J. Inorg. Biochem. 2012, 117, 212-219. https://www.sciencedirect.com/science/article/pii/S0162013412001948
del Mundo, I. M.; Siters, K. E.;Fountain, M. A.; Morrow, J. R.* “Structural Basis for Bifunctional Zn(II) Macrocyclic Complex Recognition of Thymine Bulges in DNA” Inorg. Chem. 2012, 51, 5444-5457. https://pubs.acs.org/doi/10.1021/ic3004245
Dorazio, S. J.; Morrow, J. R.* “The Development of Iron(II) Complexes as ParaCEST MRI Contrast Agents” Eur. J. Inorg. Chem. 2011, 2006-2014. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201101169
Dorazio, S. J.; Tsitovich, P. B.; Siters, K. E.; Spernyak, J. A.; Morrow, J. R.* “Iron PARACEST MRI Agents” J. Am. Chem. Soc. 2011, 133, 14154-14156. https://pubs.acs.org/doi/10.1021/ja204297z
del Mundo, I. M.; Fountain, M. A.; Morrow, J. R.* “Recognition of Thymine in DNA Bulges by a Zn(II) Macrocyclic Complex” Chem. Commun. 2011, 47,8566-8568. https://pubs.rsc.org/en/content/articlelanding/2011/cc/c1cc12074c
Hammell, J.; Buttarazzi, L.; Huang, C.-H.; Morrow, J. R.* “Eu(III) complexes as Anion-responsive Luminescent Sensors and PARACEST Agents” Inorg. Chem. 2011, 50, 4857-4867. https://pubs.acs.org/doi/full/10.1021/ic200075w
Andolina, C. M.; Morrow, J. R. “Luminescence Resonance Energy Transfer in Heterodinuclear Ln(III) Complexes for Sensing Biologically Relevant Anions” Eur. J. Inorg. Chem. 2011, 154-164. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201000779
Huang, C.-H.; Hammell, J.; Ratnakar, S. J.; Sherry, A. D.; Morrow, J. R.* “Activation of a PARACEST Agent for MRI through Selective Outersphere Interactions with Phosphate Diesters” Inorg. Chem. 2010, 49, 5963-5970. https://pubs.acs.org/doi/10.1021/ic1004616
Huang,C.-H.; Parish,A.; Samain, F.; Häner, F. Morrow, J. R.* “Binding of Europium(III) to a Non-nucleosidic Phenanthroline Linker in DNA” Bioconj. Chem. 2010, 21, 476-482. https://pubs.acs.org/doi/10.1021/bc900386w
Sánchez-Lombardo, I.; Andolina, C. M.; Morrow, J. R.*, Yatsimirsky, A. K.* “Speciation of Eu(III) hydroxo complexes in aqueous DMSO studied by Direct Excitation Luminescence Spectroscopy and their Catalytic Activity in Phosphodiester Cleavage” Dalton Trans. 2010, 39, 864-873. https://pubs.rsc.org/en/content/articlelanding/2010/dt/b918722g
Andolina, C. M.; Mathews, R. A.; Morrow, J. R.* “Solution Chemistry of Europium(III) Aqua Ion at Micromolar Concentrations as Probed by Direct Excitation Luminescence Spectroscopy” Helv. Chim. Acta 2009, 92, 2330-2348 (issue honoring Jean-Claude Bunzli). https://onlinelibrary.wiley.com/doi/abs/10.1002/hlca.200900166
Escudier, J.-M.,* Dupouy, C., Fountain, M. A.; Del Mundo, I. M. A, Jacklin, E. M.; Morrow, J. R.*“Synthesis and Luminescence Properties of a Trinucleotide-Europium(III) Complex Conjugate” Org. Biomol. Chem. 2009, 7, 3251-3257. https://pubs.rsc.org/en/content/articlelanding/2009/ob/b902643f
Nwe, K.; Morrow, Andolina, C. M. J. R.* “Dinuclear Nd(III) complexes as PARACEST agents” Bioconjugate Chem. 2009, 20(7), 1375-1382.https://pubs.acs.org/doi/10.1021/bc900146z
Huang, C.-H.; Morrow, J. R.* “Cerium(III), Europium(III), and Ytterbium(III) Complexes with Alcohol Donor Groups as Chemical Exchange Saturation Transfer Agents” Inorg. Chem. 2009, 48, 7247-7243.https://pubs.acs.org/doi/10.1021/ic900696f
Andolina, C. M.; Holthoff,W. G.; Page, P. M.; Mathews, R. A.; Morrow, J. R.;* Bright, F. V.* “Spectroscopic System for Direct Lanthanide Photoluminescence Spectroscopy with Nanomolar Detection Limits” Appl. Spectrosc., 2009,63(5), 483-493. https://journals.sagepub.com/doi/10.1366/000370209788346959
Huang, C.-H.; Morrow, J. R.* “A PARACEST Agent Responsive to Inner- and Outer-Sphere Phosphate Ester Interactions for MRI Applications” J. Am. Chem. Soc. 2009, 131, 4206-4207. https://pubs.acs.org/doi/10.1021/ja900290z
Rossiter, C. S.; Mathews, R. A.; del Mundo, I. M. A.; Morrow, J. R.* “Cleavage of a RNA Analog Containing Uridine by a Bifunctional Dinuclear Zn(II) Catalyst” J. Inorg. Biochem. 2009, 103, 64-71. https://www.sciencedirect.com/science/article/pii/S0162013408002195
Morrow, J. R. “Speed limits for artificial nucleases” Comm. Inorg. Chem., 2008, 29, 169-188. https://www.tandfonline.com/doi/abs/10.1080/02603590802551801
Humphrey, T.; Iyer, S.; Iranzo, O.; Morrow, J. R.; Richard, J. P.; Hengge, A. C.* “An Altered Transition State for the Reaction of an RNA Model Catalyzed by a Dinuclear Zinc(II) Catalyst” J. Am. Chem. Soc. 2008, 130, 17858-17866. https://pubs.acs.org/doi/10.1021/ja8059864
Nwe, K.; Andolina, C.; Morrow, J. R.* “Tethered dinuclear Eu(III) macrocyclic catalysts for the cleavage of RNA” J. Am. Chem. Soc. 2008, 130, 14861-14871. https://pubs.acs.org/doi/10.1021/ja8037799
Morrow, J. R.; Amyes, T.; Richard, J. P.* “Phosphate Binding and Catalysis by Small and Large Molecules” Acc. Chem. Res. 2008, 41, 539-548. https://pubs.acs.org/doi/10.1021/ar7002013
Nwe, Kido, Richard, John, Morrow, Janet R.* “Direct excitation luminescence spectroscopy of Eu(III) complexes of 1,4,7-tris(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane derivatives and kinetic studies of their catalytic cleavage of an RNA analog” Dalton Trans. 2007, 5171-5178. https://pubs.rsc.org/en/content/articlelanding/2007/dt/b710072h
Mathews, R.; Rossiter, C.; Richards, J. P.;* Morrow, J. R.* “A Minimalist Approach to Understanding the Efficiency of Mononuclear Zn(II) Complexes for Catalysis of Phosphodiester Cleavage” Dalton Trans. 2007, 3804-3811. https://pubs.rsc.org/en/content/articlelanding/2007/DT/b707409c
Farquhar, E.; Richard, J. P.*; Morrow, J. R.* “Formation and Stability of Mononuclear and Dinuclear Eu(III) Complexes and Their Catalytic reactivity toward Cleavage of an RNA Analog” Inorg. Chem. 2007, 46, 7169-7177. https://pubs.acs.org/doi/10.1021/ic7005666
Yang, M.Y.; Morrow, J. R.*; Richard, J. P.* “A Transition State Analog for Phosphate Diester Cleavage Catalyzed by a Metal ion Complex” Bioorg. Chem. 2007, 35, 366-374. https://www.sciencedirect.com/science/article/abs/pii/S0045206807000284
Rossiter, C.; Mathews, R.; Morrow, J. R.* “Cleavage of an RNA analog by Zn(II) Macrocyclic Catalysts Appended with a Methyl or an Acridine Group” J. Inorg. Biochem. 2007, 101, 925-934. https://www.sciencedirect.com/science/article/pii/S0162013407000487
Woods, M.; Woessner, D. E.; Zhao, P.; Pasha, A.; Yang, M. Y.; Huang, C.-H.; Vasalitiy, O.; Morrow, J. R.*; Sherry, A. D.* “Europium(III) Macrocyclic Complexes with Alcohol Pendant Arms as Chemical Exchange Saturation Transfer (CEST) Agents” J. Am. Chem. Soc. 2006, 128, 10155-10162. https://pubs.acs.org/doi/full/10.1021/ja061498t
O’Donoghue, A. M.; Pyun, S. Y.; Yang, M.-Y.; Morrow, J. R.*; Richard, J. P.* “Substrate Specificity of an Active Dinuclear Zn(II) Catalyst for Cleavage of RNA Analogs and a Dinucleoside” J. Am. Chem. Soc. 2006, 128, 1615-1621. https://pubs.acs.org/doi/10.1021/ja056167f
Rossiter, C.; Mathews, R.; Morrow, J. R.* “Uridine Binding by Zn(II) Macrocyclic Complexes: Diversion of RNA Cleavage Catalysts” Inorg. Chem. 2005, 44, 9307-9404. https://pubs.acs.org/doi/10.1021/ic050892%2B
Yang, M.Y.; Iranzo, O.; Richard, J. P.*; Morrow, J. R.* “Solvent Deuterium Isotope Effects on Phosphodiester Cleavage Catalyzed by an Extraordinarily Active Zn(II) Complex” J. Am. Chem. Soc. 2005, 127, 1064-1065. https://pubs.acs.org/doi/10.1021/ja044617i
Iranzo, O.; Khalili, H.; Epstein, D. M.; Morrow, J. R.* “Recruitment of Divalent Metal ions by Incorporation of 4-Thio-2’-deoxythymidine or 4-Thio-2’-deoxyuridine into DNA” J. Biol. Inorg. Chem. 2004, 9(4), 462-470. https://link.springer.com/article/10.1007/s00775-004-0545-0
Morrow, J. R.*; Iranzo, O. “Synthetic Metallonucleases for RNA Cleavage” Curr. Opin. Chem. Biol. 2004, 8, 192-200. https://www.sciencedirect.com/science/article/abs/pii/S1367593104000213?via%3Dihub
Iranzo, O.; Richard, J. P.*; Morrow, J. R.* “Structure-Activity Studies on the Cleavage of an RNA Analog by a Potent Dinuclear Metal ion Catalyst. The Effect of Changing the Metal Ion” Inorg. Chem. 2004, 43, 1743-1750. https://pubs.acs.org/doi/10.1021/ic035120x
Voss, D. A., Jr.; Farquhar, E. R.; Horrocks, W. DeW., Jr.; Morrow, J. R.* “Lanthanide(III) Complexes of Amide Derivative of DOTA Exhibit an Unusual Variation in Stability Across the Lanthanide Series” Inorg. Chim. Acta 2004, 357, 859-863. https://www.sciencedirect.com/science/article/pii/S0020169303003372
Yang, M.-Y., Richard, J. P.;* Morrow, J. R.* “Substrate Specificity for Catalysis of Phosphate Diester Cleavage by a Dinuclear Zn(II) Complex” Chem. Commun. 2003, 2832-2833.https://pubs.rsc.org/en/content/articlelanding/2003/cc/b308644e
Iranzo, O.; Elmer, T.; Richard, J. P.;* Morrow, J. R.* “Cooperativity Between Metal ions in the Cleavage of Phosphate Diesters and RNA by Dinuclear Zn(II) Catalysts” Inorg. Chem. 2003, 7737-7746. Featured cover article. https://pubs.acs.org/doi/10.1021/ic030131b
Iranzo, O.; Kovalevsky, A.Y.; Morrow, J. R.;* Richard, J. P.* “Physical and Kinetic Analysis of the Cooperative Role of Metal ions in Catalysis of Phosphodiester Cleavage by a Dinuclear Zn(II) Complex” J. Am. Chem. Soc. 2003, 1988-1993. https://pubs.acs.org/doi/10.1021/ja027728v
Choudhary, S.; Morrow, J. R.* “Dynamic Acylhydrazone Metal ion Complex Libraries: a Mixed Ligand Approach to Increased Selectivity in Extraction” Angew. Chem. Int. Ed. 2002, 114, 4270-4272. https://onlinelibrary.wiley.com/doi/full/10.1002/15213773(20021104)41:21%3C4096::AID-ANIE4096%3E3.0.CO;2-0
Epstein, D. M.; Choudhary, S.; Eliseev, A.; Churchill, M. R.; Keil, K. M.; Morrow, J. R.* “Chloroform-soluble Schiff-base Zn(II) or Cd(II) Complexes from a Dynamic Combinatorial Library” Inorg. Chem. 2001, 40, 1591-1596. https://pubs.acs.org/doi/10.1021/ic000938t
Wang, C.; Choudhary, S.; Vink, C.; Secord, E. A.; Morrow, J. R.* “Harnessing Thorium(IV) as a Catalyst: RNA and Phosphate Diester Cleavage by a Thorium(IV) Macrocyclic Complex” Chem. Commun. 2000, 2509-2510. https://pubs.rsc.org/en/content/articlelanding/2000/cc/b005866l
Epstein, D. M.; Chappell, L. L.; Khalili, H.; Supkowski, R. M.; Horrocks, W. DeW. Jr.; Morrow, J. R.* “Eu(III) Macrocyclic Complexes Promote Cleavage of and Bind to Models for the 5′-Cap of mRNA. Effect of Pendent Group and a Second Metal Ion” Inorg. Chem. 2000, 39, 2130-2134. https://pubs.acs.org/doi/10.1021/ic9912068
Huang, L.; Chappell, L. L.; Iranzo, O.; Baker, B. F.; Morrow, J. R.* “Oligonucleotide Conjugates of Eu(III) Tetraazamacrocycles with Pendent Alcohol and Amide groups Promote Sequence-Specific Cleavage of RNA” J. Biol. Inorg. Chem. 2000, 5(1), 85-92.https://link.springer.com/article/10.1007/s007750050011
McCue, K. P.; Morrow, J. R.* “Hydrolysis of a 5-Cap Model for mRNA by Dinuclear Cu(II) and Zn(II) Complexes. Rapid Hydrolysis by Four Metal Ions” Inorg. Chem.1999, 38, 6136-6142. https://pubs.acs.org/doi/10.1021/ic990380t
Baker, B. F.*; Lot, S. S.; Kringel, J.; Cheng-Flournoy, S.; Villiet, P.; Sasmor, H. M.; Chappell, L. L.; Morrow, J. R.* “Oligonucleotide-Europium Complex Conjugate Designed to Cleave the 5’‑Cap Structure of the ICAM-1 Transcript Potentiates Antisense Activity in Cells” Nucleic Acids Res. 1999, 27, 1547-1551. https://academic.oup.com/nar/article/27/6/1547/2902288?login=true
McCue, K.; Voss, D. A., Jr.; Marks, C.; Morrow, J. R.* “Dinuclear Copper(II) Complexes Promote Hydrolysis of GpppG, a Model for the Hydrolysis of the 5′-Cap of m-RNA” J. Chem. Soc., Dalton Trans. 1998, 2961-2962. https://pubs.rsc.org/en/content/articlelanding/1998/DT/a805916k
Chappell, L. L; Voss, D. A., Jr.; Horrocks, W. DeW., Jr.; Morrow, J. R.* “The Effect of Mixed Pendent Groups on the Solution and Catalytic Properties of Eu(III) Macrocyclic Complexes: Bifunctional and Monofunctional Amide and Alcohol Pendants in Septadentate and Octadentate Ligands” Inorg. Chem. 1998, 37, 3989-3998.https://pubs.acs.org/doi/full/10.1021/ic980191v
Baker, B.F.*; Khalili, H.; Wei, N.; Morrow, J. R.* “Cleavage of the 5′-Cap Structure of m-RNA by an Europium(III) Macrocyclic Complex with Pendant Alcohol Groups” J. Am. Chem. Soc. 1997, 119, 8749-8755.https://pubs.acs.org/doi/10.1021/ja971050f
Amin, S.; Voss, D. A., Jr.; Horrocks, W. DeW., Jr.; Morrow, J. R.* “Restoration of Catalytic Activity by Replacement of a Coordinated Amide Group: Synthesis and Laser-induced Luminescence Studies of the Phosphate Diester Transesterification Catalyst, [Eu(NBAC)]3+” Inorg. Chem. 1996, 35, 7466-7467.https://pubs.acs.org/doi/10.1021/ic9516469
Amin, S.; Marks, C.; Toomey. L.; Churchill, M. R.; Morrow, J. R.* “Synthesis of Yttrium(III) and Lutetium(III) Complexes of 1,4,7,-tris(carbamoylmethyl)-1,4,7-triazacyclononane” Inorg. Chim. Acta, 1996, 246, 99-107. https://www.sciencedirect.com/science/article/abs/pii/0020169396050566
Morrow, J. R.*; Aures, K.; Epstein, D. “Metal Ion Promoted Attack of an Alcohol on a Phosphate Diester: Modeling the Role of Metal Ions in RNA Self-Splicing Reactions” J. Chem. Soc., Chem. Commun. 1995, 2431-2432.https://pubs.rsc.org/en/content/articlelanding/1995/c3/c39950002431
Amin, S.; Voss, D. A.; Horrocks, W. DeW., Jr.; Lake, C. H.; Churchill, M. R.; Morrow, J. R.* “Laser-Induced Luminescence Studies and the Crystal Structure of the Eu(III) Complex of 1,4,7,10-tetrakis(carbamoyl)-1,4,7,10-tetraazacyclododecane. The Link Between Phosphate Diester Binding and Catalysis by Lanthanide(III) Macrocyclic Complexes” Inorg. Chem. 1995, 34, 3294-3300.https://pubs.acs.org/doi/10.1021/ic00116a023
Chin, K. O. A.; Morrow, J. R.* “RNA Cleavage and Phosphate Diester Transesterification by Encapsulated Lanthanide Ions. Traversing the Lanthanide series with Lanthanum, Europium and Lutetium Complexes of 1,4,7,10-tetrakis(2-hydroxyalkyl)-1,4,7,10-tetra-azacyclododecane” Inorg. Chem. 1994, 33, 5036-5041.https://pubs.acs.org/doi/10.1021/ic00100a031
Amin, S. A.; Morrow, J. R.*; Lake, C. H.; Churchill, M. R. “Lanthanide(III) Tetraamide Macrocyclic Complexes as Synthetic Nucleases: Structure and Catalytic Properties of [La(TCMC)(CF3SO3)(EtOH)][CF3SO3]2 (TCMC = 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane)” Angew. Chem. Int. Ed. Engl. 1994, 33, 773-775. https://doi.org/10.1002/anie.199407731
Chin, K. O. A.; Morrow, J. R.*; Lake, C. H.; Churchill, M. R. “Synthesis and Solution Properties of Lanthanum(III), Europium(III) and Lutetium(III) THP Complexes and an X-Ray Diffraction Study of a Crystal Containing Four Stereoisomers of a Europium(III) THP Complex (THP = 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane). Methyl Groups Impart Rigidity to S,S,S,S-THP Macrocyclic Complexes” Inorg. Chem. 1994, 33, 656-664. https://pubs.acs.org/doi/10.1021/ic00082a008
Kolasa, K.; Sharma, A.; Morrow, J. R.* “Lanthanide Ions Do Not Cleave RNA in DNA-RNA Hybrids” Inorg. Chem. 1993, 32, 3983-3984.https://pubs.acs.org/doi/10.1021/ic00071a002
Morrow, J. R.*; Amin, S. A.; Lake, C. H.; Churchill, M. R. “Synthesis, Structure and Dynamic Properties of the Lanthanum(III) Complex of 1,4,7,10-tetrakis(2-carbamoylethyl)-1,4,7,10-tetrazacyclododecane” Inorg. Chem. 1993, 32, 4566-4572. https://pubs.acs.org/doi/10.1021/ic00073a017
Morrow, J. R.*; Chin, K. A. “Synthesis and Dynamic Properties of Kinetically Inert Lanthanide Compounds: Lanthanum(III) and Europium(III) Complexes of 1,4,7,10-Tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane” Inorg. Chem. 1993, 32, 3357-3361. https://pubs.acs.org/doi/10.1021/ic00067a028
Morrow, J. R.*; Buttrey, L. A.; Shelton, V. M.; Berback, K. A. “Efficient Catalytic Cleavage of RNA by Lanthanide(III) Macrocyclic Complexes: Toward Synthetic Nucleases for in Vivo Applications” J. Am. Chem. Soc. 1992, 114, 1903-1905. https://pubs.acs.org/doi/10.1021/ja00031a067
Morrow, J. R.*; Buttrey, L. A.; Berback, K. A. “Transesterification of a Phosphate Diester by Divalent and Trivalent Metal Ions” Inorg. Chem. 1992, 31, 16-20. https://pubs.acs.org/doi/pdf/10.1021/ic00027a005
Shelton, V. M.; Morrow, J. R.* “Catalytic Transesterification and Hydrolysis of RNA by Zinc(II) Complexes” Inorg. Chem.1991, 30, 4295-4299. https://pubs.acs.org/doi/pdf/10.1021/ic00023a003