{"id":64,"date":"2021-12-03T14:09:31","date_gmt":"2021-12-03T14:09:31","guid":{"rendered":"https:\/\/wpdev.acsu.buffalo.edu\/heppner\/?page_id=64"},"modified":"2026-01-21T19:10:47","modified_gmt":"2026-01-21T19:10:47","slug":"publications","status":"publish","type":"page","link":"https:\/\/ubwp.buffalo.edu\/heppner\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"770\" height=\"1024\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-770x1024.jpeg\" alt=\"\" class=\"wp-image-257\" style=\"width:261px;height:auto\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-770x1024.jpeg 770w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-226x300.jpeg 226w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-768x1021.jpeg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-1155x1536.jpeg 1155w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-1540x2048.jpeg 1540w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/12\/amclct_COVER_lazertinib-1-scaled.jpeg 1925w\" sizes=\"auto, (max-width: 770px) 100vw, 770px\" \/><\/figure>\n\n\n<p><strong><em>Pre-print Manuscripts During Independent Career at UB<\/em><\/strong><span style=\"font-size: revert\"> (<sup>\u2020<\/sup><\/span><span style=\"font-size: revert\"> Corresponding Author)<\/span><\/p>\n<div>(1) Abigail M Lantry, Tahereh Damghani, Omobolanle A Abidakun, Monica R. MacDonald, <strong>David E. Heppner<\/strong><span style=\"font-size: revert\"><sup>\u2020<\/sup><\/span> &#8220;Structural Insights into the Potency of Brain-Penetrant EGFR Inhibitors&#8221; <strong>ChemRxiv 2025<\/strong> <a href=\"http:\/\/chemrxiv.org\/engage\/chemrxiv\/article-details\/6920b8a9ef936fb4a2eaa5f4\">10.26434\/chemrxiv-2025-s6gw0<\/a><\/div>\n<div class=\"FundingInformation v-div border-bottom border-thick border-inverted mt-3 px-2\" data-v-2b3ed8d6=\"\">\u00a0<\/div>\n<div>\n<p><strong><em>Publications During Independent Career at UB<\/em><\/strong><span style=\"font-size: revert\"> (<sup>\u2020<\/sup><\/span><span style=\"font-size: revert\"> Corresponding Author)<\/span><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-459\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-300x122.jpg\" alt=\"\" width=\"300\" height=\"122\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-300x122.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-1024x417.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-768x313.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-1536x625.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2026\/01\/TOC_proof-2048x834.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p><span style=\"font-weight: 400\">(30) \u00a0\u00a0\u00a0 Tahereh Damghani, Shenghan Song, Kaly S. Lin, Jianing Li, <strong>David E. Heppner<\/strong><span style=\"font-size: revert\"><sup>\u2020<\/sup><\/span> \u201cStructural Studies of Fourth-Generation EGFR Inhibitors Reveal Insights into Selective T790M and C797S targeting.\u201d <\/span><b><i>ACS Medicinal Chemistry Letters <\/i>2026 <\/b><a title=\"DOI URL\" href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.5c00725\">https:\/\/doi.org\/10.1021\/acsmedchemlett.5c00725<\/a><\/p>\n<p style=\"font-weight: 400\">(29) \u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>,<sup>\u2020<\/sup> Simone V. Bigi-Botterill, Andrew P. Riley, Kelly Chibale, Craig W. Lindsley \u201cStructural Biology Enabling Drug Discovery.\u201d <strong><em>Journal of Medicinal Chemistry <\/em>2025<\/strong>. <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03093\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03093<\/a><\/p>\n<p style=\"font-weight: 400\">(28) \u00a0\u00a0\u00a0 Meizhong Jin, Hayley Binch, <strong>David E. Heppner<\/strong>, Philip Jones \u201cIntroduction to the themed collection on kinases.\u201d \u00a0<strong><em>RSC Medicinal Chemistry <\/em>2025 <\/strong><a href=\"https:\/\/doi.org\/10.1039\/D5MD90032H\">https:\/\/doi.org\/10.1039\/D5MD90032H<\/a><\/p>\n<p style=\"font-weight: 400\">(27) \u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong><sup>\u2020<\/sup> \u201cProposed Cuts to Health Research Threaten the Future of Drug Discovery and Development\u201d \u00a0<strong><em>Journal of Medicinal Chemistry <\/em>2025 <\/strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c02080\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c02080<\/a><\/p>\n<\/div>\n<div>\u00a0<\/div>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-435\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008-300x107.jpg\" alt=\"\" width=\"300\" height=\"107\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008-300x107.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008-1024x364.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008-768x273.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008-1536x546.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/08\/images_large_jm5c01661_0008.jpg 1570w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(26) Tahereh Damghani, Surbhi P. Chitnis, Omobolanle A. Abidakun, Kishan B. Patel, Kaly S. Lin, Emily A. Ouellette, Abigail M. Lantry,\u00a0<strong>David E. Heppner<\/strong><span style=\"font-size: revert\"><sup>\u2020<\/sup><\/span>&#8220;Profiling and Optimizing Targeted Covalent Inhibitors through EGFR-Guided Studies.&#8221;\u00a0<strong>Journal of Medicinal Chemistry\u00a0<\/strong><strong>2025<\/strong> <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c01661\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c01661<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-404\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02-300x116.jpg\" alt=\"\" width=\"300\" height=\"116\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02-300x116.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02-1024x395.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02-768x297.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02-1536x593.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v02.jpg 1660w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(25) Blessing C. Ogboo, Kishan B. Patel, Marta Massari, Sara Machese, Joana Reis, Emily Joyce, Miao-chong J. Lin, Johnathan Rabb, Omobolanle Abidakun, Qing Lin, Albert van der Vliet, Andrea Mattevi, <strong>David E. Heppner<\/strong><sup>\u2020 <\/sup>\u201cEnhancing selectivity and potency of S<sub>N<\/sub>Ar Covalent Inhibitors of NADPH Oxidase Enzymes.\u201d <span style=\"font-weight: 400\"><strong>Journal of Medicinal Chemistry 2025 <\/strong> <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c01272\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c01272<\/a><\/span><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-421\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-300x120.jpg\" alt=\"\" width=\"300\" height=\"120\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-300x120.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-1024x408.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-768x306.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-1536x612.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/06\/TOC_v01-2048x817.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(24) Surbhi P. Chitnis, Florian Wittlinger, Mareike M\u00f6llers, Tyler J. Hartman, Marcel G\u00fcnther, Michael J. Eck, Stefan A. Laufer,<sup>\u2020 <\/sup><strong>David E. Heppner<\/strong><sup>\u2020<\/sup> \u201cStructure-activity relationships of inactive-conformation binding EGFR inhibitors: Linking the ATP and allosteric pockets.&#8221;<span style=\"font-weight: 400\">\u00a0\u00a0<strong>Archiv der Pharmazie 2025 <\/strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.70027\">https:\/\/doi.org\/10.1002\/ardp.70027<\/a><\/span><\/p>\n<p>(23) <strong>David E. Heppner<\/strong><span style=\"font-size: revert\"><sup>\u2020 <\/sup><\/span>&#8220;Drug Discovery and Development Faces an Ominous Future from NIH Indirect Cost Rate Cut.&#8221; <strong>Journal of Medicinal Chemistry 2025 <\/strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00444\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00444<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-390\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/02\/images_large_jm5c00326_0001-300x123.jpg\" alt=\"\" width=\"300\" height=\"123\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/02\/images_large_jm5c00326_0001-300x123.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/02\/images_large_jm5c00326_0001-1024x419.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/02\/images_large_jm5c00326_0001-768x314.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/02\/images_large_jm5c00326_0001.jpg 1300w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p class=\"wp-block-image\">(22)\u00a0<strong>David E. Heppner<\/strong><span style=\"font-size: revert\"><sup>\u2020 <\/sup><\/span>&#8220;Ascertaining a Structural Basis in Drug Discovery and Development&#8221; <strong>Journal of Medicinal Chemistry 2025 <\/strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00326\">https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00326<\/a>\u00a0<\/p>\n<div class=\"wp-block-image\"><a href=\"https:\/\/drughunter.com\/resource\/cheat-sheet-for-covalent-enzyme-inhibitors\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-385\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-300x275.avif\" alt=\"\" width=\"300\" height=\"275\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-300x275.avif 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-1024x938.avif 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-768x704.avif 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-1536x1407.avif 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/1736288996-cover-image.png-2048x1877.avif 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/div>\n<p>(21)\u00a0<strong>David E. Heppner<span style=\"font-size: revert\"><sup>\u2020<\/sup><\/span>\u00a0<\/strong>&#8220;Cheat Sheet for Covalent Enzyme Inhibitors&#8221;\u00a0<strong>Drug Hunter\u00a0<\/strong>(<a href=\"https:\/\/drughunter.com\/resource\/cheat-sheet-for-covalent-enzyme-inhibitors\">Link<\/a>) Published Jan 7, 2025\u00a0<\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-384\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1-300x128.png\" alt=\"\" width=\"300\" height=\"128\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1-300x128.png 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1-1024x437.png 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1-768x328.png 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1-1536x656.png 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2025\/01\/Picture1.png 1576w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(20) Kishan B. Patel and <b>David E. Heppner<\/b><sup>\u2020<\/sup> \u201cLazertinib: Breaking the mold of third-generation EGFR inhibitors.\u201d <strong>RSC Medicinal Chemistry 2025 <\/strong><a href=\"https:\/\/doi.org\/10.1039\/D4MD00800F\">https:\/\/doi.org\/10.1039\/D4MD00800F<\/a><\/p>\n<div>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-375\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/12\/images_large_jm4c02311_0019-300x114.jpg\" alt=\"\" width=\"300\" height=\"114\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/12\/images_large_jm4c02311_0019-300x114.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/12\/images_large_jm4c02311_0019-1024x388.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/12\/images_large_jm4c02311_0019-768x291.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/12\/images_large_jm4c02311_0019.jpg 1254w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(19) Florian Wittlinger, Surbhi P. Chitnis, Calvin D. Pham, Tahereh Damghani, Kishan B. Patel, Mareike M\u00f6llers, Ilse K. Schaeffner, Omobolanle A. Abidakun, Matthew Q. Deng, Blessing C. Ogboo, Alexander Rasch, Tyler S. Beyett, Brian Buckley, Frederic Feru, Tatiana Shaurova, Cornelius Knappe, Michael J. Eck, Pamela A. Hershberger, David A. Scott, Asher L. Brandt, Stefan A. Laufer<sup>\u2020<\/sup>, and <b>David E. Heppner<\/b><sup>\u2020<\/sup> \u201cTilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of &#8216;Type V&#8217; Kinase Inhibitors\u201d <strong>Journal of Medicinal Chemistry 2024 <\/strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02311\">https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02311<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-366\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-300x269.jpeg\" alt=\"\" width=\"300\" height=\"269\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-300x269.jpeg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-1024x917.jpeg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-768x688.jpeg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-1536x1376.jpeg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/images_large_jm4c01721_0001-2048x1835.jpeg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(18) <strong>David E. Heppner<\/strong>,<sup>\u2020<\/sup> Blessing C. Ogboo, Daniel A. Urul, Earl W. May, Erik W. Schaefer, Andrew S. Murkin, and Matthias Gehringer. &#8220;Demystifying Functional Parameters for Irreversible Enzyme Inhibitors.&#8221; <strong>Journal of Medicinal Chemistry<\/strong>\u00a0<strong>2024<\/strong> <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01721\">https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01721<\/a><\/p>\n<p>(16 &amp; 17)\u00a0<strong>David E. Heppner<\/strong>, Simone V. Bigi-Botterill, Andrew P. Riley, Kelly Chibale, and Craig W. Lindsley. &#8220;Structural Biology in Drug Discovery and Development: Call for Papers.&#8221; <strong>Journal of Medicinal Chemistry &amp; ACS Medicinal Chemistry Letters 2024 <\/strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01492\">https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01492 <\/a><a href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.4c00318\">https:\/\/doi.org\/10.1021\/acsmedchemlett.4c00318<\/a>\u00a0<\/p>\n<\/div>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-357\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/03\/Screenshot-2024-03-28-at-8.51.55\u202fAM-300x207.png\" alt=\"\" width=\"300\" height=\"207\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/03\/Screenshot-2024-03-28-at-8.51.55\u202fAM-300x207.png 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/03\/Screenshot-2024-03-28-at-8.51.55\u202fAM-1024x707.png 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/03\/Screenshot-2024-03-28-at-8.51.55\u202fAM-768x530.png 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/03\/Screenshot-2024-03-28-at-8.51.55\u202fAM.png 1060w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p><span style=\"font-size: revert\">(15) Tyler S. Beyett, Jaimin K. Rana, Ilse K. Schaeffner, <\/span><strong>David E. Heppner<\/strong><span style=\"font-size: revert\">, and Michael J. Eck \u201cStructural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase.&#8221; <b>ChemMedChem 2024 <\/b><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202300343\">https:\/\/doi.org\/10.1002\/cmdc.202300343<\/a><\/span><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-364\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/overview_graphic_can-23-1789-300x118.jpeg\" alt=\"\" width=\"300\" height=\"118\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/overview_graphic_can-23-1789-300x118.jpeg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/overview_graphic_can-23-1789-768x303.jpeg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/08\/overview_graphic_can-23-1789.jpeg 970w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(14) Nur P. Damayanti, Ricardo A. Cordova, Christopher Rupert, Ilaria Delle Fontane, Li Shen, Sabrina Orsi, Angela J. Klunk, W. Marston Linehan, Kirk A. Staschke, Peter C. Hollenhorst, <strong>David E. Heppner<\/strong>, Roberto Pili. &#8220;TFE3-splicing factor fusions represent functional drivers and draggable targets in translational renal cell carcinoma.&#8221;\u00a0<strong>Cancer Research\u00a0<\/strong><strong>2024<\/strong> <a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-23-1789\">https:\/\/doi.org\/10.1158\/0008-5472.CAN-23-1789<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone size-medium wp-image-349\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/02\/1-s2.0-S0277538724000354-ga1_lrg-300x233.jpg\" alt=\"\" width=\"300\" height=\"233\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/02\/1-s2.0-S0277538724000354-ga1_lrg-300x233.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/02\/1-s2.0-S0277538724000354-ga1_lrg-1024x794.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/02\/1-s2.0-S0277538724000354-ga1_lrg-768x595.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/02\/1-s2.0-S0277538724000354-ga1_lrg.jpg 1143w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<p>(13) <span style=\"font-size: revert\">David C. Lacy,<sup>\u2020<\/sup><\/span><span style=\"font-size: revert\">\u00a0<strong>David E. Heppner<\/strong>,<sup>\u2020<\/sup><\/span><span style=\"font-size: revert\">\u00a0Brian Buckley,<\/span><span style=\"font-size: revert\">\u00a0Justin Griffiths,<\/span><span style=\"font-size: revert\">\u00a0Parami S. Gunasekera,<\/span><span style=\"font-size: revert\">\u00a0Jully Patel,<\/span><span style=\"font-size: revert\">\u00a0Zuleydian Roche-Rivera,<\/span><span style=\"font-size: revert\">\u00a0Kelsey Coppola,<\/span><sup>\u00a0<\/sup><span style=\"font-size: revert\">Kyle Dempsey,<\/span><span style=\"font-size: revert\">\u00a0Shweta C. Pillai,<\/span><span style=\"font-size: revert\">\u00a0Bryan R. Renzoni<\/span><sup>\u00a0<\/sup>Twelve CO molecules for the price of one. A simple water-soluble organometallic CORM, [Mn(CO)<sub>3<\/sub>(\u00b5<sub>3<\/sub>-OH)]<sub>4. <\/sub><strong>Polyhedron 2024 <\/strong><em>251<\/em> 116859. <a href=\"https:\/\/doi.org\/10.1016\/j.poly.2024.116859\">https:\/\/doi.org\/10.1016\/j.poly.2024.116859<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt  wp-image-315 alignnone\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-300x169.jpg\" alt=\"\" width=\"428\" height=\"241\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-300x169.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-1024x576.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-768x432.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-1536x864.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2024\/01\/Benzo_paper_feature-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 428px) 100vw, 428px\" \/><\/div>\n<p>(12) \u00a0 Florian Wittlinger,# Blessing C. Ogboo,# Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer<sup>\u2020<\/sup>, <b>David E. Heppner<\/b><sup>\u2020<\/sup> \u201cLinking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.\u201d <strong>Communications Chemistry 2024<\/strong>,\u00a0<em>7<\/em>, Article number 38. <a href=\"https:\/\/www.nature.com\/articles\/s42004-024-01108-3\">https:\/\/www.nature.com\/articles\/s42004-024-01108-3<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone  wp-image-310\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/12\/TOC_v01-300x232.png\" alt=\"\" width=\"425\" height=\"329\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/12\/TOC_v01-300x232.png 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/12\/TOC_v01-1024x792.png 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/12\/TOC_v01-768x594.png 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/12\/TOC_v01.png 1371w\" sizes=\"auto, (max-width: 425px) 100vw, 425px\" \/><\/div>\n<p>(11) \u00a0 Kristopher W. Hoyt, Daniel A. Urul, Blessing C. Ogboo, Florian Wittlinger, Stefan A. Laufer, Erik M. Schaefner,<sup> \u2020<\/sup> Earl W. May,<sup>\u2020<\/sup> and <b>David E. Heppner<\/b>.<sup>\u2020<\/sup> \u201cPitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors.\u201d<span style=\"font-size: revert\"> <strong><em>Journal of Medicinal Chemistry<\/em> 2024<\/strong>, <em>64<\/em>, 2-16. <a title=\"DOI URL\" href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.3c01502\">doi.org\/10.1021\/acs.jmedchem.3c01502<\/a><\/span><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Highlighted in <strong><a href=\"http:\/\/practicalfragments.blogspot.com\/2024\/01\/covalent-complexities-for-kinase.html\">Practical Fragments<\/a><\/strong> (Dan Erlanson)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>(10) Justin Kim, Ilse Schaeffner, <strong>David E. Heppner<\/strong>, Ciric To, Pasi J\u00e4nne, Tyler S. Beyett and Michael J. Eck \u201cA Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology.\u201d <strong><em>Molecular Pharmacology <\/em>2024<\/strong> <em>105<\/em> 97-103. <a href=\"https:\/\/molpharm.aspetjournals.org\/content\/early\/2023\/12\/08\/molpharm.123.000768\">doi.org\/10.1124\/molpharm.123.000768<\/a><\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt alignnone  wp-image-280\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/10\/fx1_lrg-300x300.jpg\" alt=\"\" width=\"439\" height=\"439\" data-warning=\"Missing alt text\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/10\/fx1_lrg-300x300.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/10\/fx1_lrg-150x150.jpg 150w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/10\/fx1_lrg-768x768.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/10\/fx1_lrg.jpg 996w\" sizes=\"auto, (max-width: 439px) 100vw, 439px\" \/><\/div>\n<p style=\"font-weight: 400\">(9)\u00a0\u00a0\u00a0\u00a0 Debanjan Bhattacharjee, Jaweria Bakar, Surbhi P. Chitnis, Erin L. Sausville, Kumar Dilip Ashtekar, Brianna E. Mendelson, Kaitlin Long, Joan C. Smith, <strong>David E. Heppner<\/strong>,<sup>\u2020<\/sup> and Jason M. Sheltzer<sup>\u2020<\/sup>. \u201cInhibition of a lower-potency target drives the anti-cancer activity of a clinical p38 inhibitor.\u201d\u00a0<strong><em>Cell Chemical Biology<\/em><\/strong> <strong>2023<\/strong>, <em>30<\/em>, 1211-1222 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S245194562300332X\">10.1016\/j.chembiol.2023.09.013<\/a><\/p>\n<p style=\"font-weight: 400\">(8) \u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong><sup>\u2020<\/sup> \u201cDesign and development of mutant EGFR inhibitors from a structural perspective.\u201d <strong><em>Indian Journal of Biochemistry and Biophysics<\/em> 2023<\/strong>, <em>60<\/em>, 645-650. <a href=\"https:\/\/or.niscpr.res.in\/index.php\/IJBB\/article\/view\/3967\">https:\/\/doi.org\/10.56042\/ijbb.v60i9.3967<\/a>\u00a0<em>Invited Review based on talk given at the Celebrating Proteins Conference in Vadodara, India.<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-271 size-medium\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-300x296.jpg 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-1024x1010.jpg 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-768x758.jpg 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-1536x1515.jpg 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2023\/04\/1-s2.0-S0076687923001052-f2352-04-9780443152764_lrg-2048x2021.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>(7) Tahereh Damghani, Florian Wittlinger, Tyler S. Beyett, Michael J. Eck, Stefan A. Laufer, <b>David E. Heppner<\/b><sup>\u2020<\/sup> \u201cStructural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.\u201d\u00a0<span style=\"font-size: revert\">\u00a0<\/span><strong><i>Methods in Enzymology<\/i><\/strong><span style=\"font-size: revert\"> Invited Contribution.<\/span><b>\u00a02023<\/b><a href=\"https:\/\/doi.org\/10.1016\/bs.mie.2023.03.013\"><span style=\"font-size: revert\"> https:\/\/doi.org\/10.1016\/bs.mie.2023.03.013<\/span><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-246\" src=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-300x201.png\" alt=\"\" width=\"265\" height=\"177\" srcset=\"https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-300x201.png 300w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-1024x687.png 1024w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-768x515.png 768w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-1536x1030.png 1536w, https:\/\/ubwp.buffalo.edu\/heppner\/wp-content\/uploads\/sites\/181\/2022\/11\/Fig03_A_conf01_v01-2048x1373.png 2048w\" sizes=\"auto, (max-width: 265px) 100vw, 265px\" \/><\/p>\n<p>(6) <strong>David E. Heppner<\/strong>,<sup>\u2020<\/sup>\u00a0Florian Wittlinger, Tyler S. Beyett, Tatiana Shaurova, Daniel A. Urul, Brian Buckley, Calvin D. Pham, Ilse Schaeffner, Bo Yang, Blessing Ogboo, Earl W. May, Erik M. Schaefer, Michael J. Eck, Stefan A. Laufer, Pamela A. Hershberger. &#8220;Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)&#8221;\u00a0<em><strong>ACS Med. Chem. Letts.\u00a0<\/strong><\/em><strong>2022 <\/strong><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acsmedchemlett.2c00213\">https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acsmedchemlett.2c00213<\/a><\/p>\n<p>(5) Yoshihisa Kobayashi, Geoffrey R. Oxnard, Elizabeth F. Cohen, Navin R. Magadevan, Joao V. Alessi, Yin P. Hung, Arrien A. Bertram, <strong>David E. Heppner<\/strong>, Mauricio F. Rieiro, Karina P. Sacardo, Rodrigo Saddi, Mariana P. Macedo, Radael B. Blasco, Jiaqi Li, Kari J. Kurppa, Tom Nguyen, Emma Voligny, Guruprasad Ananda, Roberto Chiarle, Artur Katz, Machael Y. Tolstorukov, Lynette M. Sholl, and Pasi A. J\u00e4nne. &#8220;Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors.\u201d\u00a0<strong><em>Nature Communications<\/em> 2022<\/strong>,\u00a0<em>13<\/em>, 5614.<\/p>\n<p>(4) Blessing C. Ogboo, Uriy V. Grabovyy, Aniket Maini, Scott Scouten, Albert van der Vliet, Andrea Mattevi, &amp; <strong>David E. Heppner<\/strong><sup>\u2020 <\/sup>\u201cArchitecture of the NADPH oxidase family of enzymes\u201d.\u00a0<em><strong>Redox Biology\u00a0<\/strong><\/em><strong>2022<\/strong>, <em>52<\/em>, 102298.\u00a0[Graphical Review]<\/p>\n<p>(3)\u00a0\u00a0 Christopher M. Dustin, Aida Habibovic, Milena Hristova, Caspar Schiffers, Carolyn R. Morris, Miao-Chong Joy Lin, Robert A. Bauer, <strong>David E. Heppner<\/strong>, Nirav Daphtary, Minara Aliyeva, and Albert van der Vliet. \u201cRedox-dependent activation of Src kinase mediates epithelial IL-33 production and signaling during acute airway allergen challenge.\u201d <strong><em>The Journal of Immunology<\/em> 2021<\/strong>, <em>12<\/em>, 2989.<\/p>\n<p>(2)\u00a0\u00a0 <strong>David E. Heppner<\/strong><sup>\u2020 <\/sup>&amp; Michael J. Eck<sup>\u2020<\/sup><strong> \u201c<\/strong>A structural perspective on targeting the RTK\/Ras\/MAP kinase pathway in cancer\u201d. <strong><em>Protein Science<\/em><\/strong><strong> 2021<\/strong>, <em>30<\/em>, 1535. PMCID: <u>PMC8284588 <\/u>[Review]<\/p>\n<p>(1)\u00a0\u00a0 <strong>David E. Heppner<\/strong><sup>\u2020<\/sup><strong> \u201c<\/strong>Structural insights into redox-active cysteine residues of the Src family kinases\u201d. <strong><em>Redox Biology<\/em><\/strong><strong> 2021<\/strong>, <em>41<\/em>, 101934. PMCID: <u>PMC8022254<\/u> [Review]<\/p>\n<p><strong><em>Research Publications <\/em><\/strong>(*Equal contributions)<\/p>\n<p>(25) \u00a0\u00a0 Tyler S. Beyett, Ciric To, <strong>David E. Heppner<\/strong>, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J. H. De Clercq, Gabriel Gomez, David A. Scott, Nathanael S. Gray, Pasi A. J\u00e4nne, and Michael J. Eck. \u201cMolecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.&#8221; <strong><em>Nature Communications <\/em><\/strong><strong>2022<\/strong>,\u00a0<em>13<\/em>, 2530.<\/p>\n<p>(24) \u00a0\u00a0 Thomas W. Gero, <strong>David E. Heppner<\/strong>, Tyler S. Beyett, Ciric To, Seth C. Azevedo, Jaebong Jang, Thomas Bunnell, Frederic Feru, Zhengnian Li, Bo Hee Shin, Kara M Soroko, Prafulla Gokhale, Nathanael S. Gray, Pasi A. J\u00e4nne, Michael J. Eck, and David A. Scott. \u201cQuinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.\u201d <strong><em>Bioorganic and Medicinal Chemistry Letters<\/em><\/strong><em>\u00a0<\/em>2022, <em>3<\/em>, 402-217.<\/p>\n<p>(23) \u00a0 Ciric To, Tyler S. Beyett, Jaebong Jang, William W. Feng, Magda Bahcall, Heidi M. Haikala, Bo H Shin, <strong>David E. Heppner<\/strong>, Jaimin K. Rana, Brittaney A. Leeper, Kara M. Soroko, Michael J Poitras, Prafulla C. Gokhale, Yoshihisa Kobayashi, Kamal Wahid, Kari J. Kurppa, Thomas W. Gero, Michael Cameron, Atsuko Ogino, Mierzhati Mushajing, Chunxiao Xu, Yanxi Zhan, David A. Scott, Michael J. Eck, Nathanael S. Gray, Pasi A. J\u00e4nne.\u00a0\u201cAn allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer&#8221; <strong><em>Nature Cancer<\/em><\/strong> 2022,\u00a0<em>3<\/em>, 402-417.<\/p>\n<p>(22) \u00a0 Florian Wittlinger,* <strong>David E. Heppner,<\/strong>* Marcel G\u00fcnther, Ciric To, Bo Hee See, Jaimin K. Rana, Anna M. Schmoker, Tyler S. Beyett, Lena M. Berger, Benedict-Tilman Berger, Nicolas Bauer, James D. Vasta, Cesear R. Corona, Matthew B. Roberts, Stefan Knapp, Pasi A. J\u00e4nne, Michael J. Eck, &amp; Stefan A. Laufer \u201cDesign of a \u2018two-in-one\u2019 mutant-selective epidermal growth factor receptor inhibitor that spans the orthosteric and allosteric sites.&#8221; <strong><em>J Med. Chem. <\/em>2022<\/strong>,\u00a0<em>65<\/em>, 1370.<\/p>\n<p>(20)\u00a0\u00a0 Stephen M. Jones, <strong>David E. Heppner, <\/strong>Kenneth Vu, Daniel J. Kosman, &amp; Edward I. Solomon \u201cRapid Decay of the Native Intermediate in the Metallooxidase Fet3p Enables Controlled Fe<sup>II <\/sup>Oxidation for Efficient Metabolism.\u201d <strong><em>J Am. Chem. Soc.<\/em><\/strong> <strong>2020<\/strong>, <em>142<\/em>, 10087. PMCID: <u>PMC67315797<\/u><\/p>\n<p>(19)\u00a0\u00a0 <strong>David E. Heppner, <\/strong>Marcel G\u00fcnther, Florian Wittlinger, Stefan Laufer, &amp; Michael J. Eck \u201cStructural basis for EGFR inhibition by trisubstituted imidazole inhibitors. <strong><em>J. Med. Chem.<\/em> 2020<\/strong>, <em>63<\/em>, 4293. PMCID: <u>PMC7730863<\/u><\/p>\n<p>(18)\u00a0\u00a0 Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu, <strong>David E. Heppner<\/strong>, Jiaming Li, Jiani Long, Evanna L. Mills, John Szpyt, Zhixiang He, Guangyang Du, Ryan Garrity, Anita Reddy, Laura P. Vaites, Joao A. Paolo, Tinghu Zhang, Nathanael S. Gray, Steven P. Gygi, &amp; Edward T. Chouchani \u201cA quantitative tissue-specific landscape of protein redox regulation during aging.\u201d <strong><em>Cell<\/em><\/strong> <strong>2020<\/strong>, <em>180<\/em>, 968.<\/p>\n<p>(17)\u00a0\u00a0 Dries J. H. De Clercq,* <strong>David E. Heppner,*<\/strong> Ciric To, Jaebong Jang, Eunyoung Park, Cai-Hong Yun, Mierzhati Mushajiang, Bo Hee Shin, David A. Scott, Pasi A. J\u00e4nne, Michael J. Eck, &amp; Nathanael S. Gray \u201cDiscovery and optimization of dibenzodiazepinones as allosteric mutant-selective EGFR inhibitors.\u201d <strong><em>ACS Med. Chem. Lett.<\/em><\/strong> <strong>2019<\/strong>, <em>10<\/em>, 1549. PMCID: <u>PMC6862338<\/u><\/p>\n<p>(16)\u00a0\u00a0 Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J. H. De Clercq, Man Xu, Stephen Wang, Michael D. Cameron, <strong>David E. Heppner<\/strong>, Bo Hee Shin, Thomas W. Gero, Annan Yang, Suzanne E. Dahlberg, Kwok-Kin Wong, Michael J. Eck, Nathanael S. Gray, &amp; Pasi A. J\u00e4nne. \u201cSingle and dual targeting of mutant EGFR with an allosteric inhibitor.\u201d <strong><em>Cancer Discovery<\/em><\/strong> <strong>2019<\/strong>, <em>9<\/em>, 926. PMCID: <u>PMC6664433<\/u><\/p>\n<p>(15)\u00a0\u00a0 Andrew C. Little, Milena Hristova, Loes van Lith, Caspar Schiffers, Christopher M. Dustin, Aida Habibovic, Karamatullah Danyal, <strong>David E. Heppner<\/strong>, Maio-Chong J. Lin, Jos van der Velden, Yvonne M. Janssen-Heininger, &amp; Albert van der Vliet. \u201cDysregulated redox regulation contributes to nuclear EGFR localization and pathogenicity in lung cancer.\u201d <strong><em>Scientific Reports<\/em><\/strong> <strong>2019<\/strong>,<em> 9<\/em>, 4844. PMCID: <u>PMC63425021<\/u><\/p>\n<p>(14)\u00a0\u00a0 Nicolas Chamberlain, Bethany R. Mihavics, Emily M. Nakada, Sierra R. Bruno, <strong>David E. Heppner<\/strong>, David G. Chapman, Sidra M. Hoffman, Albert van der Vliet, Benjamin T. Suratt, Oliver Dienz, John F. Alcorn &amp; Vikas Anathy \u201cLung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.\u201d <strong><em>Redox Biology<\/em><\/strong> <strong>2019<\/strong>, <em>22<\/em>, 101129<em>. <\/em>PMCID: <u>PMC6365984<\/u><\/p>\n<p>(13)\u00a0\u00a0 <strong>David E. Heppner<\/strong>,* Christopher M. Dustin,* Chenyi Liao,* Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li, &amp; Albert van der Vliet \u201cDirect cysteine sulfenylation drives activation of the Src kinase.\u201d<strong>\u00a0 <em>Nature Communications<\/em><\/strong> <strong>2018 <\/strong><em>9<\/em>, 4522. PMCID: <u>PMC6207713<\/u><\/p>\n<p>(12)\u00a0 <strong>David E. Heppner<\/strong>, Milena Hristova, Tomoaki Ida, Ana Mijuskovic, Christopher M. Dustin, Vir\u00e1g Bogd\u00e1ndi, Jon M. Fukuto, Tobias P. Dick, P\u00e9ter Nagy, Jianing Li, Takaaki Akaike, &amp; Albert van der Vliet \u201cCysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?\u201d <strong><em>Redox Biology<\/em><\/strong> <strong>2018<\/strong>, <em>14<\/em><strong>, <\/strong>379. PMCID: <u>PMC5647513<\/u><\/p>\n<p>(11)\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Yvonne M.W. Janssen-Heininger, &amp; Albert van der Vliet \u201cThe role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies.\u201d <strong><em>Arch. Biochem. Biophys.<\/em><\/strong> <strong>2017<\/strong>, <em>616<\/em>, 40. PMCID: <u>PMC5305417<\/u><\/p>\n<p>(10)\u00a0\u00a0 Aida Habibovic, Milena Hristova, <strong>David E. Heppner<\/strong>, Karamatullah Danyal, Jennifer L. Ather, Yvonne M.W. Janssen-Heininger, Charles G. Irvin, Matthew E. Poynter, Lennart K.A. Lundblad, Anne E. Dixon, Mikl\u00f3s Geiszt, &amp; Albert van der Vliet \u201cDUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.\u201d <strong><em>JCI Insight <\/em><\/strong><strong>2016<\/strong>, <em>18<\/em>, e88811. PMCID: <u>PMC5085603<\/u><\/p>\n<p>(9) \u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Milena Hristova, Christopher M. Dustin, Karamatullah Danyal, Aida Habibovic, &amp; Albert van der Vliet \u201cThe NADPH oxidases DUOX1 and NOX2 play distinct roles in redox regulation of epidermal growth factor receptor signaling. <strong><em>J Biol. Chem. <\/em><\/strong><strong>2<\/strong><strong>016<\/strong>, <em>291<\/em>, 23282. PMCID: <u>PMC5087744<\/u><\/p>\n<p>(8)\u00a0\u00a0\u00a0\u00a0 Karamatullah Danyal, Willem de Jong, Edmund O\u2019Brien, Robert A. Bauer, <strong>David E. Heppner<\/strong>, Andrew Little, Milena Hristova, Aida Habibovic, &amp; Albert van der Vliet \u201cAcrolein and other thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.\u201d <strong><em>Am. J. Phys. Lung Cell. Mol. Phys.<\/em><\/strong> <strong>2016<\/strong>, <em>311<\/em>, L913. PMCID: <u>PMC5130541<\/u><\/p>\n<p>(7)\u00a0\u00a0\u00a0\u00a0 Andrew C. Little, Derek Sham, Milena Hristova, Karamatullah Danyal, <strong>David E. Heppner<\/strong>, Robert A. Bauer, Lynn M. Sipsey, Aida Habibovic, &amp; Albert van der Vliet \u201cDUOX1 silencing in lung cancer promotes epithelial-to-mesenchymal transition, acquisition of cancer stem cell characteristics, and invasive properties.\u201d\u00a0 <strong><em>Oncogenesis<\/em><\/strong> <strong>2016<\/strong>, <em>5<\/em>, e261. PMCID: <u>PMC5117847<\/u><\/p>\n<p>(6)\u00a0\u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Christian H. Kjaergaard, &amp; Edward I. Solomon \u201cMechanism of the reduction of the native intermediate in the multicopper oxidases: Insights into rapid intramolecular electron transfer in turnover.\u201d <strong><em>J. Am. Chem. Soc. <\/em><\/strong><strong>2014<\/strong>, <em>136<\/em>, 17788. PMCID: <u>PMC4291763<\/u><\/p>\n<p>(5)\u00a0\u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Christian H. Kjaergaard, &amp; Edward I. Solomon \u201cMolecular origin of rapid versus slow intramolecular electron transfer in the catalytic mechanism of the multicopper oxidases.\u201d <em><strong>J. Am. Chem. Soc. <\/strong><\/em><strong>2013<\/strong>, <em>135<\/em>, 12212. PMCID: <u>PMC3807568<\/u><\/p>\n<p>(4)\u00a0\u00a0\u00a0\u00a0 Bryan T. Op\u2019t Holt, Michael A. Vance, Liviu M. Mirica, <strong>David E. Heppner<\/strong>, T. Daniel P. Stack, &amp; Edward I. Solomon \u201cReaction coordinate of a functional model of tyrosinase: Spectroscopic and computational characterization.&#8221; <em><strong>J. Am. Chem. Soc. <\/strong><\/em><strong>2009<\/strong>, <em>131<\/em>, 6421. PMCID: <u>PMC2692929<\/u><\/p>\n<p>(3)\u00a0\u00a0\u00a0\u00a0 John L. Lewin, <strong>David E. Heppner<\/strong>, &amp; Christopher J. Cramer \u201cValidation of density functional modeling protocols on experimental bis(\u00b5-oxo)\/\u00b5-\u03b7<sup>2<\/sup>:\u03b7<sup>2<\/sup>-peroxo dicopper equilibria.\u201d<strong><em>J. Biol. Inorg. Chem.<\/em><\/strong> <strong>2007<\/strong>, <em>12<\/em>, 1221. PMID: <u>17710449<\/u><\/p>\n<p>(2)\u00a0\u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Benjamin F. Gherman, William B. Tolman, &amp; Christopher J. Cramer \u201cCan an ancillary ligand lead to a thermodynamically stable end-on 1:1 Cu-O<sub>2<\/sub> adduct supported by the \u03b2-diketiminate ligand?\u201d\u00a0<strong><em>Dalton Trans.<\/em><\/strong> <strong>2006<\/strong>, <em>40<\/em>, 4773. PMID: <u>17033702<\/u><\/p>\n<p>(1)\u00a0\u00a0\u00a0\u00a0 Benjamin F. Gherman, <strong>David E. Heppner<\/strong>, William B. Tolman, &amp; Christopher J. Cramer \u201cModels for dioxygen activation by the Cu<sub>B<\/sub>site of dopamine \u03b2-monooxygenase and peptidylglycine \u03b1-hydroxylating monooxygenase. <strong><em>J Biol. Inorg. Chem.<\/em><\/strong> <strong>2006<\/strong>, <em>11<\/em>, 197-205. PMID: <u>16344970<\/u><\/p>\n<p><strong>\u00a0<\/strong><strong><em>Reviews, Chapters, and Commentaries<\/em><\/strong><br \/><u><\/u>(9)\u00a0\u00a0\u00a0\u00a0 Albert van der Vliet, Christopher M. Dustin, &amp; <strong>David E. Heppner<\/strong> \u201cRedox regulation of protein kinase signaling.\u201d Chapter 16 in \u201cOxidative Stress: Eustress and Distress,\u201d H. Sies Ed., <em>Elsevier,<\/em> <strong>2020<\/strong>. [Book Chapter]<\/p>\n<p>(8)\u00a0\u00a0\u00a0\u00a0 Christopher M. Dustin, <strong>David E. Heppner, <\/strong>Maio-Chong J. Lin &amp; Albert van der Vliet \u201cRedox regulation of tyrosine kinase signaling: More than meets the eye\u201d <strong><em>J. Biochem. <\/em><\/strong><strong>2020<\/strong>,<em>167<\/em>, 151. PMCID: <u>PMC6988750<\/u> [Review]<\/p>\n<p>(7)\u00a0\u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong>, Tyler S. Beyett, &amp; Michael J. Eck \u201cA driving test for oncogenic mutations.\u201d <strong><em>J. Biol. Chem. <\/em><\/strong><strong>2019<\/strong>,<em> 24<\/em>, 9390. PMCID: <u>PMC6576455<\/u> [Editors\u2019 Pick Highlight]<\/p>\n<p>(6)\u00a0\u00a0\u00a0\u00a0 Albert van der Vliet, Karamattulah Danyal, &amp; <strong>David E. Heppner<\/strong> \u201cDual oxidase: A novel therapeutic target in allergic disease.\u201d <strong><em>Br. J. Pharmacol. <\/em><\/strong><strong>2018<\/strong>, <em>175<\/em>, 1401. PMCID: <u>PMC5900994<\/u> [Review]<\/p>\n<p>(5)\u00a0\u00a0\u00a0\u00a0 Andrew C. Little, Arvis Sulovari, Karamatullah Danyal, <strong>David E. Heppner<\/strong>, David J. Seward, &amp; Albert van der Vliet \u201cParadoxical roles of dual oxidases in cancer biology.\u201d <strong><em>Free Radic. Biol. Med. <\/em><\/strong><strong>2017<\/strong>, <em>110<\/em>, 117. PMCID: <u>PMC5535817<\/u> [Review]<\/p>\n<p>(4)\u00a0\u00a0\u00a0\u00a0 <strong>David E. Heppner<\/strong> &amp; Albert van der Vliet \u201cRedox-dependent regulation of epidermal growth factor receptor signaling.\u201d <strong><em>Redox Biology <\/em><\/strong><strong>2016<\/strong>, <em>8<\/em>, 24. PMCID: <u>PMC4710793<\/u> [Minireview]<\/p>\n<p>(3)\u00a0\u00a0\u00a0\u00a0 Edward I. Solomon, Christian H. Kjaergaard, &amp; <strong>David E. Heppner<\/strong> \u201cMolecular properties and reaction mechanism of multicopper oxidases related to their use in biofuel-cells.\u201d In \u201cElectrochemical Processes in Biological Systems,\u201d A. Lewenstam &amp; L. Groton Eds., <em>John Wiley &amp; Sons, Inc.,<\/em> Hoboken, N.J. <strong>2015<\/strong>. [Book Chapter]<\/p>\n<p>(2)\u00a0\u00a0\u00a0\u00a0 Edward I. Solomon, <strong>David E. Heppner<\/strong>, Esther M. Pierce, Jake W. Ginsbach, Jordi Cirera, Munzarin Qayyum, Matthew T. Kieber-Emmons, Christian H. Kjaergaard, Ryan G. Hadt, &amp; Li Tian \u201cCopper active sites in biology.\u201d <strong><em>Chem. Rev.<\/em><\/strong> <strong>2014<\/strong>, <em>114<\/em>, 3659. PMCID: <u>PMC4040215<\/u> [Review]<\/p>\n<p>(1)\u00a0\u00a0\u00a0\u00a0Edward I. Solomon, Jake W. Ginsbach, <strong>David E. Heppner<\/strong>, Matthew T. Kieber-Emmons, Christian H. Kjaergaard, Pieter J. Smeets, Li Tian, &amp; Julia S. Woertink. \u201cCopper dioxygen (bio)inorganic chemistry.\u201d <strong><em>Faraday Discussions<\/em><\/strong> <strong>2011<\/strong>, <em>148<\/em>, 11. PMCID: <u>PMC3062954<\/u> [Review]<\/p>","protected":false},"excerpt":{"rendered":"<p>Pre-print Manuscripts During Independent Career at UB (\u2020 Corresponding Author) (1) Abigail M Lantry, Tahereh Damghani, Omobolanle A Abidakun, Monica R. MacDonald, David E. Heppner\u2020 &#8220;Structural Insights into the Potency &hellip; <a href=\"https:\/\/ubwp.buffalo.edu\/heppner\/publications\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Publications<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":489,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-64","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/pages\/64","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/users\/489"}],"replies":[{"embeddable":true,"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/comments?post=64"}],"version-history":[{"count":73,"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/pages\/64\/revisions"}],"predecessor-version":[{"id":462,"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/pages\/64\/revisions\/462"}],"wp:attachment":[{"href":"https:\/\/ubwp.buffalo.edu\/heppner\/wp-json\/wp\/v2\/media?parent=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}