The metabolome, or the total compliment of small molecules in a living system that includes endogenous and introduced species, reflects the overall global biochemical state of an organism. Changes\u00a0in the functional genome, transcriptome and proteome are closely tied to changes in the metabolome. Metabolomics (or metabonomics) is the comprehensive measurement of the metabolome and how\u00a0it changes in response to external stressors. In Pharmaceutical R&D, this information can be used to deduce the relationship between a perturbation (such as disease or pharmacological intervention to\u00a0disease) and the affected biochemical pathways, yielding mechanistic information and biomarkers that report upon the perturbation. These biomarkers can in turn inform and accelerate the discovery of\u00a0safe and efficacious drugs. This talk will provide a background on the technology and present several examples of how it has been employed in mainstream pharmaceutical R&D.<\/p>\n
Student Lectures, 1:00 pm\u00a0in the Screening Room Keynote Presentation by Dr. Michael D. Reilly:\u00a0Pharmaceutical Applications of Metabolomics, 2:00pm in the Screening Room Student Reception and Poster Competition, 3:30 pm in … Continue reading CBE Graduate Student Research Symposium<\/span><\/a><\/p>\n","protected":false},"author":349,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[23],"class_list":["post-694","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-club-event","cat_club-event"],"_links":{"self":[{"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/tribe_events\/694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/users\/349"}],"version-history":[{"count":0,"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/tribe_events\/694\/revisions"}],"wp:attachment":[{"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/media?parent=694"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/tags?post=694"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/ubwp.buffalo.edu\/gsa\/wp-json\/wp\/v2\/tribe_events_cat?post=694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}