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The National Crystallization Center was awarded an NIH NIGMS R24 grant to become a National Resource for crystallography in 2021. As the National Crystallization Center (NCC), we support academic, government, & non-profit research institutes, providing unique protein crystallization services for structural biology.
Since beginning operations, the Crystallization Center has set up over 25 million crystallization experiments on more than 18,000 biological macromolecules for over 2,000 laboratories worldwide. Macromolecular crystallization services at UB HWI enable experiments that are monitored with state-of-the-art imaging techniques, empowering the detection of crystals that other techniques miss. Our academic, government, and non-profit services are subsidized by NIH support.
Reminder to Acknowledge the National Crystallization Center and Funding Agencies
We are grateful that NIH funding enables us to provide efficient crystallization services to academic, non-profit and government laboratories at a reduced rate. Please remember to cite the R24 grant funding for your crystallization screening experiments.
We request that the NIH R24 National Resource grant is acknowledged in any publications. We suggest the following language: Crystallization at the National Crystallization Center at UB HWI was supported through NIH grant R24GM141256.
Additionally, it would be helpful if the experimental methods references the Crystallization Center using the updated reference for the soluble and membrane screen. Citation: Budziszewski, GR, Snell, ME, Wright, TR, Lynch, ML & Bowman, SEJ (2023). High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography. J. Vis. Exp. (193), e65211.
These citations help us to track publications and PDB depositions, an important metric of productivity that will help secure future funding for the National Crystallization Center.
Crystallization at the National Crystallization Center provides:
- Expert staff: Dr. Sarah EJ Bowman has been directing the Center since being recruited to HWI in 2017 and works with a highly trained and growing team of scientists that have been doing structural biology for over two decades.
- State-of-the-art instrumentation: Brightfield (visual), second-order harmonic generation (SHG), and UV-two photon excited fluorescence (UV-TPEF) techniques in a Rock Imager 1000 with SONICC are used, so no crystal is missed.
- Timely access: High-throughput crystallization screening runs are scheduled in advance on a monthly basis with multiple setup windows.
- A history of success: The Center has worked with academic, non-profit, government and industry users, and has screened over 18,000 proteins for close to 2,000 laboratories worldwide.